HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen chloride-ethyl acetate → 1-(3-(4-Bromophenoxy)propyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen chloride-ethyl acetate | HCID 21866389 | — |
| Reactant | Tert-butyl 4-(3-(4-bromophenoxy)propyl)piperazine-1-carboxylate | HCID 86698690 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 1-(3-(4-Bromophenoxy)propyl)piperazine | HCID 18540217 | 100.3% |
Reaction Steps
To a mixture of tert-butyl 4-(3-(4-bromophenoxy)propyl)piperazine-1-carboxylate (200 mg, 0.50 mmol) in ethyl acetate (10 mL) was added HCl/ethyl acetate (20 mL). The mixture was stirred at rt for 4 hours. The mixture was concentrated to give the title compound (150 mg, 100% yield) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09394285B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-03c469f3485d4e98b1e3fe8eb164f97f |
| Source note | uspto-grants-2016_07 |