HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1-(4-Bromophenyl)cyclobutyl)methanol → 4,6-difluoro-5-(4-(1-(hydroxymethyl)cyclobutyl)phenyl)-1H-indole-3-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1-(4-Bromophenyl)cyclobutyl)methanol | HCID 58538689 | — |
| Reactant | 5-Bromo-4,6-difluoro-1H-indole-3-carbaldehyde | HCID 86698578 | — |
| Product | 4,6-difluoro-5-(4-(1-(hydroxymethyl)cyclobutyl)phenyl)-1H-indole-3-carbaldehyde | HCID 86698845 | — |
Reaction Steps
[1-(4-bromophenyl)cyclobutyl]methanol, prepared as described in Example 72 (steps 1 and 2), is treated with 5-bromo-4,6-difluoro-1H-indole-3-carbaldehyde, prepared as described in Example 6 (steps 1-4), in a manner similar as described in Example 6 step 5 to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09394285B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-0f70fc3eac984c839cfe36d25aa71b05 |
| Source note | uspto-grants-2016_07 |