(2-Amino-5-chloro-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester → {5-Chloro-2-[3-(3-imidazol-1-yl-phenyl)-3-oxo-propionylamino]-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester

HRID 105489Notes

Reaction equation

HRID 105489 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][c:8]1[c:9]([NH2:19])[cH:10][c:11]([C:15]([F:16])([F:17])[F:18])[c:12]([Cl:14])[cH:13]1)=[O:20].[C:21]([CH3:23])([CH3:24])([O:25][C:26](=[O:22])[CH2:27][C:28](=[O:29])[c:30]1[cH:31][c:32](-[n:36]2[cH:37][n:38][cH:39][cH:40]2)[cH:33][cH:34][cH:35]1)[CH3:41]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][c:8]1[c:9]([NH:19][C:26](=[O:25])[CH2:27][C:28](=[O:29])[c:30]2[cH:31][c:32](-[n:36]3[cH:37][n:38][cH:39][cH:40]3)[cH:33][cH:34][cH:35]2)[cH:10][c:11]([C:15]([F:16])([F:17])[F:18])[c:12]([Cl:14])[cH:13]1)=[O:20]

Participants

3

Reactant 2

HCID 69489727(2-Amino-5-chloro-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl esterHCID 69592789tert-Butyl 3-(3-(1H-imidazol-1-yl)phenyl)-3-oxopropanoate

Product 1

HCID 86586999{5-Chloro-2-[3-(3-imidazol-1-yl-phenyl)-3-oxo-propionylamino]-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester

Sources & evidence

ORD record
ord-0eddeb79f8bc44dcaf120708fa76c71a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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