Trifluoroacetic acid → HCID 72704325, compound

Participants

Reaction Steps

2-(2-(1-(4-methoxybenzyl)-3-(pyrrolidin-1-yl)-1H-1,2,4-triazol-5-yl)ethyl)-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine (13.6 mg, 31.4 μmol, Eq: 1.00) was stirred with trifluoroacetic acid (143 mg, 96.3 μl, 1.26 mmol, Eq: 40) and anisole (61.2 mg, 61.8 μl, 566 μmol, Eq: 18) in Dichloromethane (400 μl) overnight at room-temperature. The reaction mixture was extracted with aq. sodium borohydride sat. and dichloromethane three times, dried over magnesium sulfate, filtered and evaporated to give 5,8-Dimethyl-2-[2-(5-pyrrolidin-1-yl-2H-[1,2,4]triazol-3-yl)-ethyl]-[1,2,4]triazolo[1,5-a]pyrazine (6.6 mg, 67.2%) as off-white solid.

Provenance & Evidence