3-bromo-1-methyl-1H-1,2,4-triazole-5-carbaldehyde → (E)-2-(2-(3-bromo-1-methyl-1H-1,2,4-triazol-5-yl)vinyl)-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine

Participants

Reaction Steps

Was prepared in the same manner as described in Example 1g) using 3-bromo-1-methyl-1H-1,2,4-triazole-5-carbaldehyde (218 mg, 1.15 mmol, Eq: 1.00) and ((5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)methyl)triphenylphosphonium chloride (527 mg, 1.15 mmol, Eq: 1.00) as starting materials. Chromatography afforded 2-[(E)-2-(5-bromo-2-methyl-2H-[1,2,4]triazol-3-yl)-vinyl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine (258 mg/67.3%) as a white solid. MS: m/e=336.0334.1 (M+H+), mp: 199.4° C.

Provenance & Evidence