反应详情

温度

25 °C

A mixture of 5,7-dimethyl-2-(2-(3-(pyrrolidin-1-yl)-1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)vinyl)-[1,2,4]triazolo[1,5-a]pyrimidine (19 mg, 48.4 μmol, Eq: 1.00) and palladium on carbon 10% (5.15 mg, 4.84 μmol, Eq: 0.1) in methanol (15 ml) was stirred for 6 hours at 25° C. under hydrogen atmosphere. Evaporation of the solvent afforded 5,7-dimethyl-2-{2-[5-pyrrolidin-1-yl-2-(2,2,2-trifluoro-ethyl)-2H-[1,2,4]triazol-3-yl]-ethyl}-[1,2,4]triazolo[1,5-a]pyrimidine (19 mg/99.5%) as a white solid. MS: m/z=395.5 (M+H+), mp: 180.2° C.

1. customEvaporation of the solvent