Dichloromethane methanol → HCID 90017228, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-(2-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)vinyl)-N-ethyl-N,1-dimethyl-1H-1,2,4-triazol-3-amine (7 mg, 22.4 μmol, Eq: 1.00) and palladium on carbon 10% (4.77 mg, 4.48 μmol, Eq: 0.2) in methanol (1 ml) was stirred for 14 hours at 25° C. under hydrogen atmosphere. TLC (CH2Cl2/MeOH 19:1/UV 254 nm) showed complete reaction (spot to spot). palladium was filtered off and the filtrate was evaporated and applied on silica gel. Purification by column chromatography over 10 g SiO2 using ethyl acetate/methanol (0-10% MeOH) as eluent to give {5-[2-(5,8-Dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)-ethyl]-1-methyl-1H-[1,2,4]triazol-3-yl}-ethyl-methyl-amine (3.5 mg, 49.7%) as off-white solid

Provenance & Evidence