Dichloromethane methanol → HCID 72704536, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5,7-dimethyl-2-(2-(1-methyl-3-(pyrrolidin-1-yl)-1H-1,2,4-triazol-5-yl)vinyl)-[1,2,4]triazolo[1,5-a]pyrimidine (65 mg, 200 μmol, Eq: 1.00) and palladium on carbon 10% (42.6 mg, 40.1 μmol, Eq: 0.2) in methanol (10.0 ml) was stirred for 14 hours at 25° C. under hydrogen atmosphere. TLC (CH2Cl2/MeOH 19:1/UV 254 nm) showed complete reaction (spot to spot). palladium was filtered off and the filtrate was evaporated and dried under high vacuum to give 5,7-Dimethyl-2-[2-(2-methyl-5-pyrrolidin-1-yl-2H-[1,2,4]triazol-3-yl)-ethyl]-[1,2,4]triazolo[1,5-a]pyrimidine (34 mg, 52%) as viscous oil

Provenance & Evidence