反应详情

温度

25 °C

A mixture of N-cyclopropyl-5-(2-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)vinyl)-N,1-dimethyl-1H-1,2,4-triazol-3-amine (23 mg, 70.9 μmol, Eq: 1.00) and palladium on carbon 10% (7.55 mg, 7.09 μmol, Eq: 0.1) in methanol (3.5 ml) was stirred for 14 hours at 25° C. under hydrogen atmosphere. Palladium was filtered off, the crude material was applied on silica gel and purified by column chromatography using ethy acetate/methanol (0-10% methanol) as eluent to give N-cyclopropyl-5-(2-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)ethyl)-N,1-dimethyl-1H-1,2,4-triazol-3-amine (15 mg, 64.8%) as white waxy solid

1. filtrationPalladium was filtered off
2. custompurified by column chromatography