Water → O-(2,4,6-Trimethylbenzenesulfonyl)hydroxylamine

Participants

Role	Name	HCID	Charge
Reactant	Water	HCID 962	—
Reactant	Perchloric Acid	HCID 24247	—
Reactant	Ethyl N-[[(2,4,6-trimethylphenyl)sulfonyl]oxy]ethanimidate	HCID 2724212	—
Solvent	Tetrahydrofuran	HCID 8028	—
Product	O-(2,4,6-Trimethylbenzenesulfonyl)hydroxylamine	HCID 11830845	—

Reaction Conditions

Temperature	0 °C

Reaction Steps

70% aq. perchloric acid (4.34 g, 2.6 ml, 43.2 mmol, Eq: 4.12) was added to ethyl N-mesitylsulfonyloxyacetimidate (2.99 g, 10.5 mmol, Eq: 1.00) in THF (4 ml) at 0° C. The reaction mixture was stirred for 1 h at 0° C. The mixture was poured into water (60 ml) and extracted with CH2Cl2 (20 ml+2×10 ml). The combined organic layers were dried over Na2SO4. The solution was used without further purification in the next step.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09394311B2
Source dataset	uspto-grants-2016_07
ORD ID	ord-2e8923cb12934a938461ee3a2d975dde
Source note	uspto-grants-2016_07