2-Amino-5-chloropyridine → HCID 178425984, compound

Participants

Reaction Steps

The fresh solution of O-(mesitylsulfonyl)hydroxylamine (2.14 g, 9.96 mmol, Eq: 1.00) in CH2Cl2 prepared in the previous step was added dropwise at 0° C. to a solution of 5-chloropyridin-2-amine (1.28 g, 9.96 mmol, Eq: 1.00) in CH2Cl2 (20 ml). The suspension was stirred for 20 min and then filtered. The residue was washed with DCM and dried under high vacuum to give the desired product as a white powder (2.5 g, 73%). MS m/z=144.03 (M−MsO+H+)

Provenance & Evidence