HCID 90017261, compound → HCID 90017411, compound

HRID 1054972Notes

Reaction equation

HRID 1054972 reaction equation
[CH3:1][C:2]1[N:7]2[N:8]=[C:9](/[CH:11]=[CH:12]/[C:13]3[N:17]([CH3:18])[N:16]=[C:15]([N:19]4[CH2:23][CH2:22][CH2:21][CH2:20]4)[N:14]=3)[N:10]=[C:6]2[CH:5]=[CH:4][C:3]=1[CH3:24]>C(O)(=O)C.[Pd]>[CH3:1][C:2]1[N:7]2[N:8]=[C:9]([CH2:11][CH2:12][C:13]3[N:17]([CH3:18])[N:16]=[C:15]([N:19]4[CH2:23][CH2:22][CH2:21][CH2:20]4)[N:14]=3)[N:10]=[C:6]2[CH:5]=[CH:4][C:3]=1[CH3:24]

Participants

4

Reactant 1

HCID 90017261HCID 90017261, compound

Product 1

HCID 90017411HCID 90017411, compoundYield 99.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

(E)-5,6-Dimethyl-2-(2-(1-methyl-3-(pyrrolidin-1-yl)-1H-1,2,4-triazol-5-yl)vinyl)-[1,2,4]triazolo[1,5-a]pyridine (45 mg) and Pd/C (5 mg) were stirred in acetic acid (0.7 ml) under hydrogen for 1 h. The mixture was filtered and concentrated to give the product (45 mg, 99.4%) as a light yellow solid. MS: m/z=326.2 (M+H+)

Workup

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-112050da7c06415aab9e3d81f1c651cf
Source dataset
uspto-grants-2016_07
Patent number
US09394311B2

Reaction notes

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