Ethyl isothiocyanatoformate → ethyl-N-[(3,6-dimethylpyrazin-2-yl)carbamothioyl]carbamate

Participants

Reaction Conditions

Reaction Steps

To a solution of 3,6-dimethyl-pyrazin-2-ylamine (5 g, 40.65 mmol) in dioxane (150 ml) was added ethoxycarbonyl isothiocyanate (4.75 ml, 40.65 mmol) at 25° C., and the reaction mixture was stirred for 18 hours at 25° C. Volatiles were removed in vacuo. The resultant residue was dissolved in ethyl acetate, washed with water twice, and brine, dried over anhydrous sodium sulfate, filtered, and evaporated affording ethyl-N-[(3,6-dimethylpyrazin-2-yl)carbamothioyl]carbamate (10 g, 96.73%) as a light yellow solid. MS: m/z=255 (M+H+)

Provenance & Evidence