Sodium periodate → HCID 83878940, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-(1-methyl-5-(2-methylprop-1-enyl)-1H-1,2,4-triazol-3-yl)piperidine (376 mg, 1.71 mmol, Eq: 1.00), sodium periodate (1.46 g, 6.83 mmol, Eq: 4), osmium tetroxide 4% aq. (325 mg, 325 μl, 51.2 μmol, Eq: 0.03) and benzyltriethylammonium chloride (155 mg, 683 μmol, Eq: 0.4) in dioxane (17.9 ml) and water (4.12 ml) was stirred for 1.5 hours at 70° C. The mixture was diluted with ethyl acetate and washed 2× with water and brine. The organic layer was separated, dried over magnesium sulfate, filtrated and evaporated affording 2-methyl-5-piperidin-1-yl-2H-[1,2,4]triazole-3-carbaldehyde (331 mg, 99.9%) as a brown waxy solid. MS: m/z=195.4 (M+H+)

Provenance & Evidence