HCID 90026195, compound → HCID 72705091, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (E)-5,8-dimethyl-2-(2-(1-methyl-3-(piperidin-1-yl)-1H-1,2,4-triazol-5-yl)vinyl)-[1,2,4]triazolo[1,5-a]pyrazine (52 mg, 154 μmol, Eq: 1.00) and palladium on carbon 10% (16.4 mg, 15.4 μmol, Eq: 0.1) in methanol (20 ml) was stirred for 24 hours at 25° C. under a hydrogen atmosphere. The catalyst was filtered off, the filtrate was evaporated affording 5,8-dimethyl-2-[2-(2-methyl-5-piperidin-1-yl-2H-[1,2,4]triazol-3-yl)-ethyl]-[1,2,4]triazolo[1,5-a]pyrazine (30 mg, 57.4%) as a yellow oil. MS: m/z=341.5 (M+H+)

Provenance & Evidence