HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 72705092, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 83891736 | HCID 83891736 | — |
| Reactant | HCID 178437625 | HCID 178437625 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 72705092 | HCID 72705092 | 100% |
Reaction Steps
HATU (40.5 mg, 106 μmol, Eq: 1.5) and N,N-diisopropylethylamine (27.5 mg, 37.2 μL, 213 μmol, Eq: 3) were added to 3-(1-methyl-3-(pyrrolidin-1-yl)-1H-1,2,4-triazol-5-yl)propanoic acid in dimethylformamide (1 ml). The mixture was stirred for 10 min at room temperature. 3-Amino-2-ethyl-5-methylpyrimidin-4(3H)-iminium 2,4,6-trimethylbenzenesulfonate was added, and the mixture was stirred at 100° C. for 1 h. The product (2.7 mg, 100%) was obtained as a white solid after purification by preparative HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09394311B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-c6c26a9aba0e4eea8867e749b38899d4 |
| Source note | uspto-grants-2016_07 |