HCID 90018158, compound → HCID 72705093, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (E)-5,8-dimethyl-2-(2-(1-methyl-3-(2-methylpyrrolidin-1-yl)-1H-1,2,4-triazol-5-yl)vinyl)-[1,2,4]triazolo[1,5-a]pyrazine (50 mg, 148 μmol, Eq: 1.00) and palladium on carbon 10% (31.4 mg, 29.5 μmol, Eq: 0.2) in methanol (20 ml) was stirred for 5 hours at 25° C. under hydrogen atmosphere. The catalyst was filtered off, the filtrate was evaporated affording 5,8-dimethyl-2-{2-[2-methyl-5-(2-methyl-pyrrolidin-1-yl)-2H-[1,2,4]triazol-3-yl]-ethyl}-[1,2,4]triazolo[1,5-a]pyrazine (49 mg, 97.4%) as a colorless viscous oil. MS: m/z=341.5

Provenance & Evidence