1-methyl-3-(pyrrolidin-1-yl)-1H-1,2,4-triazole-5-carbaldehyde → 5,8-dimethyl-2-[(E)-2-(2-methyl-5-pyrrolidin-1-yl-2H-[1,2,4]triazol-3-yl)-vinyl]-[1,2,4]triazolo[1,5-c]pyrimidine

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Reaction Steps

Was prepared in the same manner as described in Example 81a) using 1-methyl-3-(pyrrolidin-1-yl)-1H-1,2,4-triazole-5-carbaldehyde (30 mg, 166 μmol, Eq: 1.00) and ((5,8-dimethyl-[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)methyl)triphenylphosphonium chloride (76.4 mg, 166 μmol, Eq: 1.00) (prepared as described in WO2011150156, pp 123-125, Expl. 24 g) affording 5,8-dimethyl-2-[(E)-2-(2-methyl-5-pyrrolidin-1-yl-2H-[1,2,4]triazol-3-yl)-vinyl]-[1,2,4]triazolo[1,5-c]pyrimidine (27 mg, 50.0%) as light yellow amorphous. MS: m/z=325.6 (M+H+)

Provenance & Evidence