HCID 90017406, compound → HCID 90026082, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (E)-N-cyclopropyl-5-(2-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)vinyl)-N-ethyl-1-methyl-1H-1,2,4-triazol-3-amine (75 mg, 222 μmol, Eq: 1.00) and palladium on carbon 10% (11.8 mg, 11.1 μmol, Eq: 0.05) in methanol (15 ml) was stirred for 5 hours at 25° C. under hydrogen atmosphere. The catalyst was filtered off, the filtrate was evaporated affording cyclopropyl-{5-[2-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)-ethyl]-1-methyl-1H-[1,2,4]triazol-3-yl}-ethyl-amine (65 mg, 86.2%) as a light yellow viscous oil. MS: m/z=341.5 (M+H+)

Provenance & Evidence