Sodium Acetate → HCID 90017823, compound

Participants

Reaction Conditions

Reaction Steps

The mixture of 5-(dichloromethyl)-1-(4-methoxybenzyl)-3-(pyrrolidin-1-yl)-1H-1,2,4-triazole and 3-(dichloromethyl)-1-(4-methoxybenzyl)-5-(pyrrolidin-1-yl)-1H-1,2,4-triazole from the previous step (299 mg, 0.876 mmol, Eq: 1) was suspended in ethanol (5 ml) and water (5 ml). Sodium acetate (180 mg, 2.2 mmol, Eq: 5) was added. The reaction mixture was heated for 16 h at 60° C. The mixture was extracted with ethyl acetate. The combined organic layers were dried over sodium sulfate. The product (74 mg, 29%) was obtained as a yellow solid by column chromatography (SiO2, ethyl acetate n-heptane). MS: m/z=287.3 (M+H+)

Provenance & Evidence