Bisulfite → HCID 90017778, compound

Participants

Reaction Conditions

Reaction Steps

5-Chloro-6-methyl-3-methylsulfanyl-pyridin-2-ylamine (160 mg, 848 μmol, Eq: 1.00) and oxone (1.56 g, 2.54 mmol, Eq: 3) were combined in methanol (15 ml) to give an off-white suspension. The mixture was cooled to 0° C., and water (30 ml) was added dropwise, followed by 39% hydrogen sulfite (1.5 ml) and saturated sodium bicarbonate solution (6 ml). The mixture was stirred for 10 min and then extracted with ethyl acetate. The combined organic layers were dried over sodium sulfate and concentrated to an oil. The product (88 mg, 47%) was obtained as a white solid by chromatography (SiO2, ethyl acetate/n-heptane). MS: m/z=221.2 (M+H+)

Provenance & Evidence