Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Heptane | HCID 8900 | — |
| Reactant | HCID 72702892 | HCID 72702892 | — |
| Reactant | HCID 178477796 | HCID 178477796 | — |
| Catalyst | Dichloro(1,1'-(1,3-propanediyl)bis(1,1-diphenylphosphine-kappaP))nickel | HCID 2724937 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 72702894 | HCID 72702894 | 62.1% |
Reaction Steps
1 M dimethylzinc in heptane (70 μL, 70 μmol, Eq: 1.00) was added to 6-bromo-5-methyl-2-[2-(2-methyl-5-pyrrolidin-1-yl-2H-[1,2,4]triazol-3-yl)-ethyl]-8-trifluoromethyl-[1,2,4]triazolo[1,5-a]pyridine (30 mg, 65.5 μmol, Eq: 1.00) and 1,3-bis(diphenylphosphino)propane-nickel(II) chloride (13 mg, 24.0 μmol, Eq: 0.366) in dioxane (1 ml). The mixture was heated to 100° C. for 1 h in a microwave oven. Purification by preparative HPLC gave the desired product (16 mg, 61.7%) as a white solid. MS: m/z=394.4 (M+H+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09394311B2 |
|---|
| Source dataset | uspto-grants-2016_07 |
|---|
| ORD ID | ord-70266498bbd0409caf2936d8abc009a3 |
|---|
| Source note | uspto-grants-2016_07 |
|---|
