反应详情

温度

25 °C

A mixture of (E)-1-(5-(2-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)vinyl)-1-methyl-1H-1,2,4-triazol-3-yl)pyrrolidin-2-one (24 mg, 70.9 μmol, Eq: 1.00) and palladium on carbon 10% (7.5 mg, 7.1 μmol, Eq: 0.1) in methanol (15 ml) was stirred for 5 hours at 25° C. under hydrogen atmosphere. Additional catalyst (0.1 eq) was added and hydrogenation continued for another 6 hours until HPLC shows complete conversion. The catalyst was filtered off, the filtrate was evaporated affording 1-{5-[2-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)-ethyl]-1-methyl-1H-[1,2,4]triazol-3-yl}-pyrrolidin-2-one (24 mg, 99.4%) as a colorless oil. MS: m/z=341.6 (M+H+)

1. waithydrogenation continued for another 6 hours until HPLC
2. filtrationThe catalyst was filtered off
3. customthe filtrate was evaporated