反应详情

温度

100 °C

A mixture of 3-methyl-but-2-enoic acid 1-methylsulfanyl-1-pyrrolidin-1-yl-meth-(Z)-ylidene amide (1.2 g, 5.3 mmol) and hydrazine solution was stirred for 2 hours at 100° C. in a sealed tube. The mixture was cooled and concentrated. The crude material was purified by combiflash column chromatography using 50% ethyl acetate in hexane to give 5-(2-methyl-propenyl)-3-pyrrolidin-1-yl-1H-[1,2,4]triazole (300 mg, 29.39%) as a white solid. MS: m/z=193 (M+H+)

1. temperatureThe mixture was cooled
2. concentrationconcentrated
3. customThe crude material was purified by combiflash column chromatography