Potassium Carbonate → HCID 90025225, compound

Participants

Reaction Conditions

Reaction Steps

1-Bromo-2-methoxyethane (10.7 mg, 7.26 μl, 77.3 μmol, Eq: 1.2) was added to 6-chloro-5-methyl-2-(2-(1-methyl-3-(pyrrolidin-1-yl)-1H-1,2,4-triazol-5-yl)ethyl)-[1,2,4]triazolo[1,5-a]pyridin-8-ol (23.3 mg, 64.4 μmol, Eq: 1.00) and K2CO3 (26.7 mg, 193 μmol, Eq: 3) in dimethylformamide (1 ml). The mixture was stirred at 50° C. for 2 h. The crude material was purified by preparative HPLC to give the desired product (7 mg, 25%) as a white powder. MS: m/z=420.6 (M+H+)

Provenance & Evidence