Trifluoroacetic acid → HCID 90017353, compound

Participants

Reaction Steps

Trifluoroacetic acid (9.87 g, 6.67 ml, 86.5 mmol, Eq: 100) was added to 6-chloro-2-(2-(1-(4-methoxybenzyl)-3-(pyrrolidin-1-yl)-1H-1,2,4-triazol-5-yl)ethyl)-5-methyl-8-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridine (450 mg, 865 μmol, Eq: 1.00). The mixture was heated under reflux for 4 h and then concentrated to an oil. Water (15 ml) was added and the mixture was alkalized by addition of sodium bicarbonate. The mixture was extracted with dichloromethane. The combined organic layers were dried over sodium sulfate and concentrated to an oil. The crude product was purified by chromatography (SiO2, methanol ethyl acetate) to afford the product (140 mg, 40.5%) as an off white solid. MS: m/z=400.2 (M+H+)

Provenance & Evidence