HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile--water (1/1) → (S)-2-(5-fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)-3,3-dimethylbutane-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile--water (1/1) | HCID 18373917 | — |
| Reactant | (S)-2-(5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-4-ylamino)-3,3-dimethylbutan-1-ol | HCID 71247626 | — |
| Product | (S)-2-(5-fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)-3,3-dimethylbutane-1-ol | HCID 71251247 | — |
Reaction Steps
Alcohol, 32, was synthesized in a manner similar to compound 70a utilizing the same deprotection procedure, starting with compound 54a: 1H NMR (400 MHz, CDCl3) δ 10.77 (brs, 1H), 8.25 (d, J=8.4 Hz, 1H), 8.07 (s, 1H), 8.03 (s, 1H), 7.88 (s, 1H), 5.59 (brs, 1H), 4.36 (t, J=8.3 Hz, 2H), 4.11 (m, 1H), 3.72 (m, 2H), 1.06 (s, 9H); LC/MS (10-90% ACN/water 5 min with 0.9% FA) m/z 348.13 (M+H) RT=1.83 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09394302B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-e23a5af938fc4fb8bb08031917fcef1c |
| Source note | uspto-grants-2016_07 |