HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formic Acid → HCID 178445895, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | methyl (3R)-3-[(2-chloro-5-fluoropyrimidin-4-yl)amino]-4,4-dimethylpentanoate | HCID 86714731 | — |
| Reactant | HCID 178427251 | HCID 178427251 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 178445895 | HCID 178445895 | — |
Reaction Steps
Compound 5 was synthesized in a manner similar to compound 12, starting with compound 6a: 1H NMR (400 MHz, d6-DMSO) δ 12.65 (s, 1H), 9.43 (s, 1H), 9.15 (s, 1H), 8.44 (d, J=4.7 Hz, 1H), 8.41-8.29 (m, 2H), 3.93 (s, 1H), 3.54 (s, 1H), 1.19 (d, J=20.0 Hz, 9H); LCMS Gradient 10-90%, 0.1% formic acid, 5 minutes, C18/ACN, Retention Time=2.70 min, (M+H) 393.32.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09394302B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-ac273acb949641e7a4d1b64710111d21 |
| Source note | uspto-grants-2016_07 |