Toluene → HCID 131736346, compound

Participants

Reaction Steps

A solution of 20.00 g (0.24 mol) diketene in 250 ml toluene was added dropwise at 0° C. to a solution of 33.21 g (0.24 mol) glycine ethyl ester hydrochloride (amino acetic ester hydrochloride). 40.00 g (0.48 mol) NaHCO3 were then added and the reaction mixture was stirred further at room temperature overnight. Since no starting material could be detected anymore by thin-layer chromatography, the reaction mixture was spun off, and the obtained solid was taken up in 100 ml diethylether, stirred for a short period of time, filtrated off and dried overnight under vacuum. 40.00 g of product was obtained as a white solid.

Provenance & Evidence