2-Methoxyethylamine → N-(2-methoxyethyl)-3-oxobutanamide

Participants

Reaction Conditions

Reaction Steps

33 ml (0.38 mol) methoxyethylamine were added dropwise to a solution of 30 g of diketene (0.36 mol) in 300 ml tetrahydrofuran at −5 to 0° C. After 1 h stirring at 0° C. no more starting material was detected by thin layer chromatography. The reaction mixture was evaporated and the residue purified by column chromatography. This gave 47.15 g (0.30 mol, 83% yield) of a white solid.

Provenance & Evidence