Diketene → HCID 43579635, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 25 g (0.22 mol) 2-piperidinemethanol in 200 ml tetrahydrofuran was added dropwise to a solution of 18 g of diketene (0.2 mol) in 200 ml tetrahydrofuran at −5 to 0° C. After 1 h stirring at 0° C. no more starting material was detected by thin layer chromatography. The reaction mixture was evaporated and the residue purified by column chromatography. This gave 32.40 g (0.17 mol, 76% yield) of a colorless oil.

Provenance & Evidence