Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diketene | HCID 12661 | — |
| Reactant | (3S)-pyrrolidin-3-ol | HCID 2733874 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 53468219 | HCID 53468219 | 77% |
Reaction Steps
A solution of 21.8 g (0.25 mol) (S)-3-pyrrolidinol in 200 ml tetrahydrofuran was added dropwise to a solution of 20 g of diketene (0.24 mol) in 200 ml of tetrahydrofuran at −5 to 0° C. added. After 1 h stirring at 0° C. no more starting material was detected by thin layer chromatography. The reaction mixture was evaporated and the residue purified by column chromatography. This gave 31.35 g (0.18 mol, 77% yield) of a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09394324B2 |
|---|
| Source dataset | uspto-grants-2016_07 |
|---|
| ORD ID | ord-758d1142e9664b9b872b2c64585a8a84 |
|---|
| Source note | uspto-grants-2016_07 |
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