Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diketene | HCID 12661 | — |
| Reactant | 4-Methoxypiperidine | HCID 77666 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 60933053 | HCID 60933053 | 71% |
Reaction Steps
15 g (0.13 mol) of 4-methoxy-piperidine were added dropwise to a solution of 10.4 g of diketene (0.12 mol) in 200 ml tetrahydrofuran at −5 to 0° C. After 1 h stirring at 0° C. no more starting material was detected by thin layer chromatography. The reaction mixture was evaporated and the residue purified by column chromatography. This gave 17.0 g (0.085 mol, 71% yield) of a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09394324B2 |
|---|
| Source dataset | uspto-grants-2016_07 |
|---|
| ORD ID | ord-ba6a02e877ee4685902f8bd180ca6695 |
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| Source note | uspto-grants-2016_07 |
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