Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diketene | HCID 12661 | — |
| Reactant | N-Aminomorpholine | HCID 20315 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 23283750 | HCID 23283750 | 78% |
Reaction Steps
18 ml (0.19 mol) of 4-Aminomorpholine were added dropwise to a solution of 15 g of diketene (0.18 mol) in 200 ml tetrahydrofuran at −5 to 0° C. After 1 h stirring at 0° C. no more starting material was detected by thin layer chromatography. The reaction mixture was evaporated and the residue purified by column chromatography. This gave 26.1 g (0.14 mol, 78% yield) of a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09394324B2 |
|---|
| Source dataset | uspto-grants-2016_07 |
|---|
| ORD ID | ord-c6de5927a93a480db42a352b1e4d607d |
|---|
| Source note | uspto-grants-2016_07 |
|---|
