Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diketene | HCID 12661 | — |
| Reactant | Ethyl 4-piperidinecarboxylate | HCID 70770 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 3107398 | HCID 3107398 | — |
Reaction Steps
A solution of 18.70 g (0.12 mol) ethyl 4-piperidinecarboxylate in 50 ml tetrahydrofuran was added dropwise to a solution of 10.00 g of diketene (0.12 mol) in 200 ml tetrahydrofuran at −5 to 0° C. After 1 h stirring at 0° C. no more starting material was detected by thin layer chromatography. The reaction mixture was evaporated and the residue purified by column chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09394324B2 |
|---|
| Source dataset | uspto-grants-2016_07 |
|---|
| ORD ID | ord-6d32e9071caa42658c9963afad45749c |
|---|
| Source note | uspto-grants-2016_07 |
|---|
