Hydroxylamine → HCID 86685711, compound

Participants

Reaction Steps

To a solution of 3-methoxy-4-[2-(2-oxoimidazolidin-1-yl)ethoxy]benzaldehyde (25.6 g, 0.097 mol) in EtOH (250 mL) at 52° C. is added a solution of hydroxylamine (10.2 g, 0.155 mol, 50% in water, Aldrich) in EtOH (20 mL). The reaction medium is then stirred for 4.5 hours between 50 and 60° C. The reaction medium is then concentrated under reduced pressure (Tbath=42° C., 60 mbar) so as to obtain a residue of 70-80 mL. The precipitate obtained is filtered, washed with an EtOH/water mixture (twice 5 mL/15 mL) and dried under atmospheric pressure at room temperature.

Provenance & Evidence