Potassium Hydroxide → HCID 90037501, compound

Participants

Reaction Conditions

Reaction Steps

KOH (1.44 g, 25.6 mmol, Eq: 6) in H2O (20 mL) was added to as solution of ethyl 2-(dibenzylamino)-2-(1-hydroxycyclohexyl)acetate (1.63 g, 4.27 mmol, Eq: 1.00) in MeOH (60 mL) and the mixture was heated to 60° C. After 18 h the reaction was cooled to RT and diluted with 100 mL H2O. The pH of the reaction was adjusted to about 4 using sat. KHSO4, and extracted with EtOAc. The combined extracts were washed with H2O, dried over Na2SO4 and concentrated the title compound as a white foam (1.44 g, 95%) which was used without purification. MS m/e 354.1 (MH+).

Provenance & Evidence