HCID 90039259, compound → HCID 90037993, compound

Participants

Reaction Conditions

Reaction Steps

3-(Dibenzylamino)-8,9-difluoro-2′,3′,5′,6′-tetrahydro-3H-spiro[benzo[b][1,4]oxazepine-2,4′-pyran]-4(5H)-one (100 mg, 215 μmol, Eq: 1.00) was added to MeOH (10 mL) and the mixture warmed 40° C. to give a light yellow suspension. 20% Pd(OH)2/C (100 mg, 215 μmol, Eq: 1.00) was added, the mixture was degassed and stirred at RT under H2 for 6.5 h. The mixture was filtered through Celite and concentrated under reduced pressure to afford 3-amino-8,9-difluoro-2′,3′,5′,6′-tetrahydro-3H-spiro[benzo[b][1,4]oxazepine-2,4′-pyran]-4(5 h)-one (60 mg, 98% yield) as colorless oil which was used without purification. MS m/z 285.0 (MH+)

Provenance & Evidence