1,2-Difluoro-3-nitrobenzene → HCID 90037828, compound

HRID 1055397Notes

Reaction equation

HRID 1055397 reaction equation
[NH2:1][CH:2]1[C:8]2([CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[O:7][C:6]2[C:14]([F:19])=[C:15](F)[CH:16]=[CH:17][C:5]=2[NH:4][C:3]1=[O:20].FC1C(F)=CC=CC=1[N+]([O-])=O>>[NH2:1][CH:2]1[C:8]2([CH2:9][CH2:10][O:11][CH2:12][CH2:13]2)[O:7][C:6]2[C:14]([F:19])=[CH:15][CH:16]=[CH:17][C:5]=2[NH:4][C:3]1=[O:20]

Participants

3

Reactant 2

HCID 813351,2-Difluoro-3-nitrobenzeneHCID 90037993HCID 90037993, compound

Product 1

HCID 90037828HCID 90037828, compound

Procedure

In a similar manner to that described for the preparation of 3-amino-8,9-difluoro-2′,3′,5′,6′-tetrahydro-3H-spiro[benzo[b][1,4]oxazepine-2,4′-pyran]-4(5H)-one except in step 4 the mixture was hydrogenated overnight, 2,3-difluoronitrobenzene (4.48 g, 2.98 mL, 28.1 mmol) was converted to the title compound as a beige solid (480 mg) which was used without purification. MS m/z 266.9 (MH+)

Sources & evidence

ORD record
ord-c77557382c1842b9a7b2ae05c5c1f68c
Source dataset
uspto-grants-2016_07
Patent number
US09394263B2

Reaction notes

Loading…