反应详情

According to the method of Example 1, Step C, deprotection was performed (room temperature, 2 hours) by using Intermediate 92 (40.4 mg) and 10% hydrogen chloride/methanol solution (2 ml). The solvent was evaporated under reduced pressure, and the residue was added with methanol (1 ml) and diethyl ether (3 ml). The deposited precipitates were collected by filtration and washed with diethyl ether to obtain the title compound (37.8 mg) as light yellow powdery solid.

1. custom(room temperature, 2 hours)
2. customThe solvent was evaporated under reduced pressure
3. additionthe residue was added with methanol (1 ml) and diethyl ether (3 ml)
4. customThe deposited precipitates
5. filtrationwere collected by filtration
6. washwashed with diethyl ether