反应详情

NaBH4 (49.8 mg, 1.32 mmol, Eq: 0.3) was added to a solution of 1-ethyl-1H-indole-4-carbaldehyde (800 mg, 4.39 mmol, Eq: 1.00) in EtOH (30 mL) and DCM (15 mL) at 0° C. and the mixture was warmed to RT and stirred overnight. The mixture concentrated to remove DCM and the resulting mixture diluted with NH4Cl, extracted with DCM and concentrated. The residue was purified by silica gel chromatography to give the title compound (700 mg, 91%) as a yellow oil.

1. concentrationThe mixture concentrated
2. customto remove DCM
3. additionthe resulting mixture diluted with NH4Cl
4. extractionextracted with DCM
5. concentrationconcentrated
6. customThe residue was purified by silica gel chromatography