Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-Fluorobenzonitrile | HCID 67855 | — |
| Reactant | 3-Methyl-1H-indole-2-carbonitrile | HCID 593371 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 90037382 | HCID 90037382 | 94.7% |
Reaction Steps
A mixture of 3-methyl-1H-indole-2-carbonitrile (500 mg, 3.2 mmol), 2-fluorobenzonitrile (388 mg, 3.2 mmol) and Cs2CO3 (1.05 g, 3.2 mmol) in DMF (10 mL) was heated at 60° C. overnight. The mixture was poured into H2O and a precipitate formed. The solid was collected by filtration, washed with H2O and hexane, and dried under vacuum to give 1-(2-cyanophenyl)-3-methyl-1H-indole-2-carbonitrile (780 mg, 94.6%) as an off white solid that was used without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09394263B2 |
|---|
| Source dataset | uspto-grants-2016_07 |
|---|
| ORD ID | ord-64051bb5bd894dc69ab7f1c804b95350 |
|---|
| Source note | uspto-grants-2016_07 |
|---|
