反应详情

NaBH4 (255 mg, 6.73 mmol) was added to a suspension of 2-(difluoromethoxy)-1-naphthaldehyde (0.997 g, 4.49 mmol) in EtOH (29.9 mL). After 3 h the mixture was diluted with H2O, extracted with EtOAc, the combined extracts were washed with brine (200 mL), dried over Na2SO4, filtered, and the filtrate concentrated to give a residue that was purified by silica gel chromatography to provide (2-(difluoromethoxy)naphthalen-1-yl)methanol (387 mg, 39%) as an orange solid.

1. extractionextracted with EtOAc
2. washthe combined extracts were washed with brine (200 mL)
3. dry with materialdried over Na2SO4
4. filtrationfiltered
5. concentrationthe filtrate concentrated
6. customto give a residue that
7. customwas purified by silica gel chromatography