Hydrochloric Acid → HCID 73056590, compound

Participants

Reaction Steps

1 M HCl in Et2O (2 mL, 2.00 mmol, Eq: 26.7) was added to a solution of tert-butyl (S)-1-(5-benzyl-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-ylamino)-1-oxopropan-2-yl(methyl)carbamate (35 mg, 75 μmol, Eq: 1.00) in MeOH (1 mL). After 2 h at RT, the mixture was stored in a freezer overnight, removed from the freezer and stirred an additional 2 h at RT. The mixture was concentrated, the residue dissolved in MeCN/H2O, and lyophilized to afford the title compound (25 mg, 83%). MS m/z 370.0 (MH+)

Provenance & Evidence