Hydrochloric Acid → HCID 73057818, compound

Participants

Reaction Steps

Hydrogen chloride gas was bubbled into a solution of ((S)-1-{(R)-9-[2-(2-methoxy-ethoxy)-acetylamino]-5-naphthalen-1-ylmethyl-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-ylcarbamoyl}-ethyl)-methyl-carbamic acid tert-butyl ester (70 mg, 108 μmol) in dioxane (5 mL) at 0° C. for 1 min, the mixture was warmed to RT and stirred for 1 h. The mixture was concentrated, the residue was triturated with Et2O and the resulting solid was filtered, washed with Et2O and dried to give the title compound (25 mg, 40%). HR-MS: calcd for C29H34N4O5S (MH+) 551.2326. found 551.2323.

Provenance & Evidence