HRID1055449

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID69329

1-(Bromomethyl)-4-chlorobenzene

C7H6BrCl

结构：C[C@@H](C(=O)N[C@H]1COc2ccccc2NC1=O)N(C)C(=O)OC(C)(C)C

HCID72713380

未命名化合物

PRODUCTS

生成物

结构：CN[C@@H](C)C(=O)N[C@H]1COc2ccccc2N(Cc2ccc(Cl)cc2)C1=O

HCID73054591

未命名化合物

收率 61.2%

PROCEDURE

实验过程

In a similar manner to that described for Example 45 except in Step 2 the material obtained after chromatography was not triturated, tert-butyl methyl((S)-1-oxo-1-((S)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-ylamino)propan-2-yl)carbamate (173 mg, 476 iumol) and 1-(bromomethyl)-4-chlorobenzene (103 mg, 500 μmol) were converted to the title compound (113 mg) as an off-white foam. HRMS: calcd. for C20H22N3O3Cl: (MH+) 388.1422. found 388.1423.

WORKUP

后处理

customobtained after chromatography
customwas not triturated