Hydrochloric Acid → HCID 73055430, compound

Participants

Reaction Steps

A mixture of 3 M HCl in dioxane (36.0 g, 30 mL, 120 mmol, Eq: 1660) and tert-butyl (S)-1-((S)-5-((6-fluoro-1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)methyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-ylamino)-1-oxopropan-2-yl(methyl)carbamate (40 mg, 72.4 μmol, Eq: 1.00) were stirred at RT overnight. The mixture was diluted with sat. NaHCO3 and extracted with DCM The combined extracts were washed with H2O and concentrated. The residue was purified was purified by preparative TLC to give the title compound (26 mg, 95%) as a white solid. MS m/z 453 (MH+)

Provenance & Evidence