Glycolaldehyde dimer → HCID 73055734, compound

Participants

Reaction Steps

Na(OAc)3BH (14.2 mg, 67.0 μmol, Eq: 1.4) was added to a solution of (S)-2-amino-N-((S)-5-((1-(2-cyanophenyl)-1H-indazol-3-yl)methyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)propanamide (23 mg, 47.9 μmol, Eq: 1.00) and glycolaldehyde dimer (3.16 mg, 26.3 μmol, Eq: 0.55) in DCM (1.5 mL). After 72 h. at RT, the mixture was diluted with NaHCO3 and extracted with DCMThecombined extracts were concentrated. The residue was purified by preparative TLC to give the title compound (16 mg, 95%) as a solid. MS m/z 525 (MH+)

Provenance & Evidence