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HRID1055480

反应详情

EQUATION

反应方程式

HRID 1055480 的结构方程式

REACTANTS

反应物

1
结构：CC[C@H](N)C(=O)N[C@H]1COc2ccccc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O.Cl
HCID90038089

未命名化合物

PRODUCTS

生成物

1
结构：CC[C@H](N)C(=O)N[C@H]1COc2ccccc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O
HCID90036882

未命名化合物

收率 99.9%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO.ClCCl
溶剂HCID21226129

未命名化合物

PROCEDURE

实验过程

A solution of (S)-2-amino-N-((S)-5-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)butanamide hydrochloride (283 mg) in 25% MeOH/CH2Cl2 was treated with silica-supported carbonate (SiliCycle, 3 eq) for 1 h, filtered, and the filtrate concentrated to provide (S)-2-amino-N -((S)-5-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)butanamide (264 mg) as a white foam. MS m/z 512/514 (MH)+

WORKUP

后处理

  1. filtrationfiltered
  2. concentrationthe filtrate concentrated