Hydrochloric Acid → HCID 73056912, compound

Participants

Reaction Steps

2 M solution of HCl in Et2O (1.26 mL) was added to a solution of tert-butyl methyl((S)-1-((S)-5-((2-methylnaphthalen-1-yl)methyl)-4-oxo-9-(trifluoromethyl)-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-ylamino)-1-oxopropan-2-yl)carbamate (66 mg, 113 μmol) in MeOH (400 μL) After 2.5 h the mixture was concentrated, MeCN was added to the residue and the mixture concentrated. The residue was lyophilized from MeCN/H2O to afford the title compound (48 mg, 82%) as a white powder. MS m/z 486 (MH)+

Provenance & Evidence